Often used for:
Leukemia, brain tumors, germ cell tumors, retinoblastoma, lymphoma, neuroblastoma, Ewing sarcoma, Wilms tumor, other solid tumors
About etoposide
Etoposide slows or stops cancer cell growth. It may be given orally or by IV, with dosing schedules depending on cancer type, age, and route. Patients will have regular blood tests and blood pressure checks before and after IV doses.
Possible late effects
- Secondary acute leukemias
Etoposide at home
- Store capsules in the refrigerator; swallow whole without crushing or chewing.
- Liquid etoposide may be stored at room temperature and mixed with orange juice or flavored syrup just before dosing; discard syringes after each use.
- If a dose is missed, take it as soon as possible unless close to the next dose; do not double doses.
- Do not use beyond the labeled expiration date.
- Follow safe handling and disposal guidance.
Possible side effects
- Low blood pressure (IV)
- Liver problems
- Hair loss
- Nausea and vomiting
- Loss of appetite
- Low blood counts (infection, bleeding, anemia, fatigue)
- Mouth sores
- Diarrhea
- Skin irritation or rash
- Stomach pain
- Weakness or fatigue
- Numbness or tingling in hands or feet
- Not all patients will experience these side effects. Report any symptoms to the care team.
Tips for patients and families
- Discuss all questions with your doctor or pharmacist.
- Avoid grapefruit or Seville orange products during therapy.
- Use birth control during treatment and for 6 months afterward.
- Inform the care team if pregnant or breastfeeding.
- Follow safe handling and disposal instructions; caregivers should avoid contact with patient body fluids for 48 hours after dosing.
